叶酸对健康受试者苯妥英动力学的影响。
Effects of folic acid on phenytoin kinetics in healthy subjects.
作者信息
Furlanut M, Benetello P, Avogaro A, Dainese R
出版信息
Clin Pharmacol Ther. 1978 Sep;24(3):294-7. doi: 10.1002/cpt1978243294.
PMID:688723
Abstract
Phenytoin (DPH) disposition was studied in normal subjects before and after treatment with folic acid for 14 days. Our results suggest that folic acid lowers (DPH) serum levels without significantly modifying its bound fraction and increases the rate of DPH and meta-hydroxydiphenylhydantoin excretion in urine.
摘要
在正常受试者中，研究了叶酸治疗14天前后苯妥英（DPH）的处置情况。我们的结果表明，叶酸可降低（DPH）血清水平，而不会显著改变其结合分数，并增加尿液中DPH和间羟基二苯乙内酰脲的排泄率。
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