Niles L P, Brown G M, Mishra R K
J Neurosci Res. 1983;10(1):53-60. doi: 10.1002/jnr.490100107.
The effects of blinding with or without pineal ablation on brain monoamine levels were studied in male rats. Brain dopamine (DA), norepinephrine (NE), epinephrine (E), and serotonin (5-HT) were measured by radioenzymatic assays. Four weeks following pinealectomy, E levels were significantly enhanced in the frontal cortex. Chronic blinding decreased striatal DA levels and increased striatal 5-HT levels in both sham-operated and pinealectomized (Px) animals. In a second experiment Px animals were sacrificed 1 or 7 d after pinealectomy in order to examine the short-term effects of pinealectomy. There were no differences between controls and Px animals in their cortical levels of DA, NE, and E and their hippocampal and hypothalamic 5-HT levels. However, the E concentrations measured 1 d after surgery were significantly greater than after 7 d. The implications of these findings with regard to the reported role of the pineal and melatonin in brain homeostasis and endocrine regulation are discussed.
在雄性大鼠中研究了有无松果体切除的致盲对脑单胺水平的影响。通过放射酶法测定脑多巴胺（DA）、去甲肾上腺素（NE）、肾上腺素（E）和5-羟色胺（5-HT）。松果体切除术后四周，额叶皮质中的E水平显著升高。在假手术和松果体切除（Px）的动物中，长期致盲均降低了纹状体DA水平并升高了纹状体5-HT水平。在第二个实验中，为了检查松果体切除的短期影响，在松果体切除术后1天或7天处死Px动物。对照组和Px动物在皮质DA、NE和E水平以及海马和下丘脑5-HT水平上没有差异。然而，术后1天测得的E浓度显著高于7天后。讨论了这些发现对于松果体和褪黑素在脑内稳态和内分泌调节中所报道作用的意义。
