Shaw W, Long G, McHan J
J Anal Toxicol. 1983 May-Jun;7(3):119-22. doi: 10.1093/jat/7.3.119.
A sensitive, accurate, and precise method for the analysis of clonazepam in serum was developed. The drug and internal standard from serum extracts were methylated to obviate carbamazepine interference and then resolved on a 5 micron C18 HPLC column. The mobile phase could also be used for many other basic drugs.
开发了一种灵敏、准确且精密的血清中氯硝西泮分析方法。血清提取物中的药物和内标进行甲基化以消除卡马西平的干扰，然后在5微米C18高效液相色谱柱上分离。该流动相也可用于许多其他碱性药物。
