Folkerd E J, James V H
J Steroid Biochem. 1983 Jul;19(1B):687-90. doi: 10.1016/0022-4731(83)90236-4.
The action of glucocorticoids on aromatase activity in human adipose tissue has been investigated. Oestrogen production was increased in tissue maintained in the presence of dexamethasone and cortisol. Dexamethasone was effective at concentrations as low as 1 nmol/l. In contrast, over the 40 h incubation period, cortisol was only effective at concentrations in excess of 500 nmol/l, although after conditions of prolonged incubation, induction of aromatase activity was measurable using cortisol concentrations as low as 28 nmol/l. There were apparent variations in both basal levels of aromatic activity and in response to glucocorticoids in adipose tissue taken from various sites within the body.
已对糖皮质激素对人体脂肪组织中芳香化酶活性的作用进行了研究。在存在地塞米松和皮质醇的情况下，组织中的雌激素生成增加。地塞米松在低至1 nmol/l的浓度下就有效。相比之下，在40小时的孵育期内，皮质醇仅在超过500 nmol/l的浓度下才有效，不过在延长孵育条件下，使用低至28 nmol/l的皮质醇浓度就可检测到芳香化酶活性的诱导。取自身体不同部位的脂肪组织中，芳香活性的基础水平以及对糖皮质激素的反应均存在明显差异。
