Wolff C, Wahlen W, Neis K J
Padiatr Padol. 1983;18(3):247-61.
Palpable indurations, calcified nodules, osseous plates and clasps in shoulder, upper arms, thighs and in the back and pelvis muscles are typical signs for several progressive diseases or are associates with some systemic diseases of youth. These changes imply greatly decreased range of motion of all limb joints and increasing retardation of growth and development and often lead to early death. Although often described, the etiology of these diseases is not known. We observed some years ago a particularly serious case, where the connective tissue of almost all the muscles of the skeleton, the subcutis and the ligaments of the limb joints were penetrated by amorphous calcifications and moreover ectopic ossifications were seen in the perirenal adipose tissue and in the interstitial adipose and connective tissue of the striped muscles. Ossifications and calcifications respectively are typical for different diseases, and therefore in our described case it was difficult to decide for a definitive diagnosis.
肩部、上臂、大腿以及背部和骨盆肌肉处可触及的硬结、钙化结节、骨板和扣状物是几种进行性疾病的典型体征，或与一些青少年全身性疾病相关。这些变化意味着所有肢体关节的活动范围大幅减小，生长发育迟缓加剧，且常导致过早死亡。尽管这些疾病常被描述，但病因不明。几年前我们观察到一个特别严重的病例，几乎全身骨骼肌肉、皮下组织以及肢体关节韧带的结缔组织都被无定形钙化穿透，此外，在肾周脂肪组织以及横纹肌的间质脂肪和结缔组织中还可见异位骨化。骨化和钙化分别是不同疾病的典型表现，因此在我们描述的病例中，很难做出明确诊断。
