超氧化物歧化酶（EC 1.15.1.1）、锰以及乙醇对成年和胎鼠的影响。

Superoxide dismutase (EC 1.15.1.1), manganese and the effect of ethanol in adult and foetal rats.

Dreosti I E, Manuel S J, Buckley R A

Br J Nutr. 1982 Sep;48(2):205-10. doi: 10.1079/bjn19820106.

Abstract

The activity of manganese-superoxide dismutase (EC 1.15.1.1; SOD) was increased in the livers and kidneys of adult rats after exposure to aqueous ethanol (200 ml/1) for 32 weeks. 2. The concentration of Mn in the livers and kidneys was significantly higher after 24 weeks, and by 32 weeks liver copper and zinc levels were lower. 3. The activity of foetal (day 19) liver superoxide dismutase was appreciably higher in offspring from dams receiving ethanol during pregnancy. Quantitatively the response appeared to be almost entirely due to the Mn-SOD form of the enzyme. 4. Maternal alcoholism during pregnancy had no effect on the levels of Cu, Mn or Zn in foetal (day 19) livers.

摘要

成年大鼠暴露于含水乙醇（200毫升/1）32周后，其肝脏和肾脏中锰超氧化物歧化酶（EC 1.15.1.1；SOD）的活性增加。2. 24周后肝脏和肾脏中的锰浓度显著升高，到32周时肝脏铜和锌水平降低。3. 在孕期摄入乙醇的母鼠所产后代中，胎肝（第19天）超氧化物歧化酶的活性明显更高。从数量上看，这种反应似乎几乎完全归因于该酶的锰超氧化物歧化酶形式。4. 孕期母亲酗酒对胎肝（第19天）中铜、锰或锌的水平没有影响。