Tso W W, Lee C S
Contraception. 1982 Jun;25(6):649-55. doi: 10.1016/0010-7824(82)90066-x.
Gossypol, a promising male contraceptive isolated from cottonseed oil, inhibits spermatozoal motility. This antimotility effect accompanies a biphasic change in the spermatozoal respiratory rate: a stimulation at low concentrations and an inhibition at high concentrations. With various respiratory inhibitors, gossypol was shown to take effect by the uncoupling of the respiratory chain and the oxidative phosphorylation. The implication of this uncoupling action in the strategy of producing an ideal gossypol-like male contraceptive is discussed.
棉酚是从棉籽油中分离出来的一种很有前景的男性避孕药，它能抑制精子的活力。这种抗活力作用伴随着精子呼吸速率的双相变化：低浓度时刺激，高浓度时抑制。使用各种呼吸抑制剂时，棉酚被证明是通过呼吸链与氧化磷酸化的解偶联起作用的。本文讨论了这种解偶联作用在生产理想的棉酚类男性避孕药策略中的意义。
