棉酚对精子活力作用的分子机制。

Molecular mechanisms of gossypol action on sperm motility.

Breitbart H, Mayevsky A, Nass-Arden L

Department of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

Int J Biochem. 1989;21(10):1097-102. doi: 10.1016/0020-711x(89)90049-9.

Abstract

Gossypol acetic acid inhibits collective motility of ejaculated ram spermatozoa. 2. Oxygen consumption was stimulated at low gossypol concentrations and inhibited as the concentrations are increased. 3. Gossypol inhibits respiration of permeabilized spermatozoa supported by durohydroquinome, which indicates a direct inhibition of mitochondrial electron transport chain. 4. The rapid reduction of mitochondrial dependent motility, high uncoupling effect and almost complete inhibition of mitochondrial calcium accumulation, indicate that gossypol inhibits motility in a mechanism by which mitochondrial uncoupling is involved.

摘要

醋酸棉酚抑制射出的公羊精子的集体运动。2. 在低棉酚浓度下氧消耗受到刺激，而随着浓度增加则受到抑制。3. 棉酚抑制由杜氢醌支持的透化精子的呼吸作用，这表明对线粒体电子传递链有直接抑制作用。4. 线粒体依赖性运动的快速降低、高解偶联效应以及线粒体钙积累几乎完全受到抑制，表明棉酚通过涉及线粒体解偶联的机制抑制运动。