Gregerson D S, Abrahams I W, Puklin J E
Ophthalmology. 1982 Jul;89(7):767-71. doi: 10.1016/s0161-6420(82)34725-9.
Using the enzyme-linked immunosorbent assay, the serum antibody titers to bovine retinal S-antigen and rod outer segments in pre- and post-argon laser treated diabetic retinopathy patients were compared to each other and to the titers of age- and sex-matched normal controls. The increase in anti-S titer following the initial laser treatment gave a P less than 0.01 using the two-tailed paired Student's t-analysis as compared to the prelaser anti-S titer. Both pre- and post-laser anti-S titers were elevated over normal controls with P values of less than 0.02 and less than 0.001, respectively. Eight weeks after the initial laser treatment, anti-S titers began to decline approaching control levels 12 weeks later. No significant change was found between pre- and post-laser titers when rod outer segments were used as antigen although the pre- and post-laser titers were increased over normal controls with P values of less than 0.05 and less than 0.001, respectively. The release and possible alteration of retinal components following photocoagulation may account for the rise in anti-S titers, while the prephotocoagulation titers may be due to retinopathy-related photoreceptor cell alteration.
采用酶联免疫吸附测定法，比较了氩激光治疗前后糖尿病视网膜病变患者血清中针对牛视网膜S抗原和视杆外段的抗体滴度，并与年龄和性别匹配的正常对照组的滴度进行了比较。与激光治疗前的抗S滴度相比，初次激光治疗后抗S滴度的升高经双尾配对学生t检验，P值小于0.01。激光治疗前和治疗后的抗S滴度均高于正常对照组，P值分别小于0.02和小于0.001。初次激光治疗8周后，抗S滴度开始下降，12周后接近对照水平。当视杆外段用作抗原时，激光治疗前后的滴度之间未发现显著变化，尽管激光治疗前和治疗后的滴度均高于正常对照组，P值分别小于0.05和小于0.001。光凝后视网膜成分的释放和可能的改变可能是抗S滴度升高的原因，而光凝前的滴度可能是由于视网膜病变相关的光感受器细胞改变。
