Bermond P
Acta Vitaminol Enzymol. 1982;4(1-2):45-54.
Studies carried out in different countries during the last 15 years have provided evidence that supplementation with (or excess of) estro-progestational hormones may be accompanied by an increased urinary excretion of tryptophan metabolites, as happens in pyridoxine deficiency. Further methods of assessment of vitamin B6 in humans have confirmed an impaired status in women using hormonal contraception. Disturbances in the metabolism of tryptophan have been shown to be responsible for such symptoms as depression, anxiety, decrease of libido and impairment of glucose tolerance occurring in some of the OCA users. Administration of 40 mg of vitamin B6 daily not only restores normal biochemical values but also relieves the clinical symptoms in those vitamin B6 deficient women taking OCA's. Further studies are justified to clarify whether vitamin B6 supplementation may contribute to improving depression also in other situations with hyperoestrogenism (pregnancy, puerperium, estro-progestational treatments, etc.), as well as correcting metabolic impairments, such as a minor alteration of glucose tolerance.
过去15年在不同国家开展的研究已提供证据表明，补充（或过量摄入）雌孕激素可能伴随着色氨酸代谢产物尿排泄增加，就像在维生素B6缺乏时那样。评估人体维生素B6的进一步方法已证实，使用激素避孕的女性其维生素B6状态受损。色氨酸代谢紊乱已被证明是某些口服避孕药使用者出现抑郁、焦虑、性欲减退和糖耐量受损等症状的原因。每日服用40毫克维生素B6不仅能恢复正常生化值，还能缓解那些服用口服避孕药且维生素B6缺乏的女性的临床症状。进一步的研究是有必要的，以阐明补充维生素B6是否也有助于改善其他雌激素过多情况（怀孕、产褥期、雌孕激素治疗等）下的抑郁，以及纠正代谢障碍，如糖耐量的轻微改变。
