Wenk G L, Stemmer K L
Neurotoxicology. 1982 Jul;3(1):93-9.
We have investigated the possible interactions between the dietary intake of copper, zinc, or aluminum and the activities of the enzymes dopamine-beta-hydroxylase (DBH, EC.1.14.2.1) and phenylethanolamine-N-methyltransferase (PNMT, EC.2.1.1.28) in the male rat brain. Exposure to aluminum was for 120 days at 1000 ppm. The results showed that a diet suboptimal in copper or zinc decreased the activity of both enzymes in the three brain regions studied, including the frontal cortex, hippocampus, and cerebellum. The addition of aluminum to the suboptimal zinc diet restored the activity of both enzymes to within range of control values. The data are discussed with respect to an interaction between zinc and aluminum.
我们研究了雄性大鼠大脑中铜、锌或铝的饮食摄入量与多巴胺-β-羟化酶（DBH，EC.1.14.2.1）和苯乙醇胺-N-甲基转移酶（PNMT，EC.2.1.1.28）的酶活性之间可能存在的相互作用。以1000 ppm的浓度让大鼠接触铝，持续120天。结果表明，铜或锌含量欠佳的饮食会降低所研究的三个脑区（包括额叶皮质、海马体和小脑）中这两种酶的活性。在锌含量欠佳的饮食中添加铝可使这两种酶的活性恢复到对照值范围内。我们根据锌与铝之间的相互作用对这些数据进行了讨论。
