Wenk G L, Stemmer K L
Neurotoxicology. 1981 Oct;2(2):347-53.
The clinical and neuropathological effects of elevated brain aluminum levels have only recently been described. The clinical symptoms, and localization of aluminum in the brain, suggest an altered catecholamine balance. We report the effects of elevated brain aluminum upon the endogenous steady-state levels of norepinephrine and dopamine in the frontal cortex, hippocampus and cerebellum. The neurotoxic effects of ingested aluminum are shown to be dependent upon the dietary intake of copper, zinc, iron, and magnesium. Norepinephrine levels in the cortex and cerebellum decreased in rats fed a low copper diet with aluminum added (0.1%, w/w). Suboptimal iron levels decreased norepinephrine in the cerebellum. The presence of aluminum in diets low in copper or zinc decreased dopamine levels in the cortex. The data are interpreted with respect to the clinical symptomatologies seen in demented, chronic renal dialysis patients with depressed serum copper and zinc levels.
脑铝水平升高的临床及神经病理学影响直到最近才被描述。临床症状以及铝在脑中的定位表明儿茶酚胺平衡发生了改变。我们报告了脑铝水平升高对额叶皮质、海马体和小脑中去甲肾上腺素和多巴胺内源性稳态水平的影响。结果表明，摄入铝的神经毒性作用取决于铜、锌、铁和镁的饮食摄入量。在添加铝（0.1%，w/w）的低铜饮食喂养的大鼠中，皮质和小脑中的去甲肾上腺素水平降低。铁水平欠佳会降低小脑中的去甲肾上腺素。低铜或低锌饮食中存在铝会降低皮质中的多巴胺水平。这些数据是根据患有血清铜和锌水平降低的痴呆慢性肾透析患者所出现的临床症状来解读的。
