Lippard S J
Science. 1982 Dec 10;218(4577):1075-82. doi: 10.1126/science.6890712.
The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.
顺二氯二氨合铂（II）（顺铂）具有临床可用的抗肿瘤特性且能形成铂蓝这一发现，引发了对其在水中化学性质的广泛研究。几种新分子已被合成，一些相当古老的分子也首次得到了表征，并且关于顺铂与其可能的生物靶点DNA的化学相互作用的线索已开始显现。
