Janssen D L, Bartz C R, Bush M, Marchwicki R H, Grate S J, Montali R J
J Am Vet Med Assoc. 1982 Dec 1;181(11):1225-7.
Parvovirus enteritis developed in 10 of 17 vaccinated juvenile bush dogs (Speothos venaticus) from 4 litters in a 5-month period. Nine dogs died. The first outbreak involved 6 of 9 bush dogs from 2 litters. Each had been vaccinated with a killed feline-origin parvovirus vaccine at 11 and 14 weeks of age. The 6 affected dogs became ill at 29 weeks of age and died. The second outbreak involved a litter of 6 bush dogs. Each had been vaccinated every 2 weeks starting at 5 weeks of age. Two were isolated from the colony at 16 weeks of age for treatment of foot sores. Three of the 4 nonisolated dogs developed parvovirus enteritis at 20 weeks of age; 2 died at 6 and 8 days, respectively, after onset of signs. The 3rd outbreak involved a litter of 2 bush dogs. Both had been vaccinated every 2 to 3 weeks, starting at 6 weeks of age. One of these dogs became ill at 17 weeks and died 13 days later. A litter of 6 maned wolves (Chrysocyon brachyurus) and a litter of 3 bush dogs were isolated from their parent colonies at 13 and 15 weeks of age, respectively. Each animal had been vaccinated weekly, beginning at 8 weeks of age, using an inactivated canine-origin parvovirus vaccine. None of the isolated animals developed the disease. Serologic testing during isolation did not reveal protective titers (greater than or equal to 1:80) against canine parvovirus in the bush dogs until they were 23 weeks old, whereas protective titers developed in the maned wolves when they were 14 to 18 weeks old. One hand-raised bush dog was vaccinated weekly, beginning at 8 weeks of age, and a protective titer developed by 21 weeks of age. It was concluded that the juvenile bush dogs went through a period during which maternal antibodies interfered with immunization, yet did not protect against the disease. When the pups were isolated from the colony during this period, then vaccinated repeatedly until protective titers developed, the disease was prevented.
在5个月的时间里，来自4窝的17只接种过疫苗的幼年丛林犬（薮犬）中有10只患上了细小病毒肠炎。9只狗死亡。首次疫情涉及来自2窝的9只丛林犬中的6只。每只狗在11周龄和14周龄时都接种了灭活的猫源细小病毒疫苗。这6只受感染的狗在29周龄时发病并死亡。第二次疫情涉及一窝6只丛林犬。每只狗从5周龄开始每2周接种一次疫苗。其中2只在16周龄时从群体中隔离出来治疗足部溃疡。4只未隔离的狗中有3只在20周龄时患上细小病毒肠炎；其中2只在出现症状后的第6天和第8天死亡。第三次疫情涉及一窝2只丛林犬。两只狗从6周龄开始每2至3周接种一次疫苗。其中一只狗在17周龄时发病，13天后死亡。一窝6只鬃狼（鬃狼）和一窝3只丛林犬分别在13周龄和15周龄时从其亲本群体中隔离出来。每只动物从8周龄开始每周接种一次灭活的犬源细小病毒疫苗。没有一只隔离的动物患上这种疾病。隔离期间的血清学检测显示，丛林犬在23周龄之前没有针对犬细小病毒的保护性抗体效价（大于或等于1:80），而鬃狼在14至18周龄时产生了保护性抗体效价。一只人工饲养的丛林犬从8周龄开始每周接种疫苗，到21周龄时产生了保护性抗体效价。得出的结论是，幼年丛林犬经历了一个时期，在此期间母源抗体干扰了免疫，但并未预防疾病。当幼犬在此期间从群体中隔离出来，然后反复接种疫苗直至产生保护性抗体效价时，疾病就得到了预防。
