Vetulani J, Sansone M, Oliverio A
Pharmacol Biochem Behav. 1982 Nov;17(5):967-71. doi: 10.1016/0091-3057(82)90481-6.
The influence of pimozide on the effects of apomorphine on locomotor activity and stereotypy was studied in two inbred strains of mice. In C57BL/6 mice, in which apomorphine did not produce stereotypy of gnawing, the biphasic effect of apomorphine on locomotor activity (hypomotility followed by hypermotility) was unaffected by pimozide. In DBA/2 mice, in which high doses of apomorphine produce hypomotility and compulsive gnawing, both these effects (but not hypomotility produced by low doses of apomorphine) were counteracted by pimozide. The results are consistent with the assumption that both strains of mice have separate inhibitory and stimulatory dopamine receptors mediating locomotor activity. In addition, DBA/2 but not C57BL/6 mice have dopamine receptors which mediate stereotypy and are sensitive to pimozide.
在两个近交系小鼠中研究了匹莫齐特对阿扑吗啡对运动活性和刻板行为影响的作用。在C57BL/6小鼠中，阿扑吗啡不会产生啃咬刻板行为，阿扑吗啡对运动活性的双相作用（运动减少后运动增多）不受匹莫齐特影响。在DBA/2小鼠中，高剂量阿扑吗啡会产生运动减少和强迫性啃咬，这两种作用（但低剂量阿扑吗啡产生的运动减少不受影响）均被匹莫齐特抵消。这些结果与以下假设一致，即两种品系的小鼠具有介导运动活性的单独的抑制性和刺激性多巴胺受体。此外，DBA/2小鼠而非C57BL/6小鼠具有介导刻板行为且对匹莫齐特敏感的多巴胺受体。
