Nikulina E M, Skrinskaya J A, Popova N K
Behavioural Phenogenetics Laboratory, Siberian Branch of the Academy of Sciences of the USSR, Novosibirsk.
Psychopharmacology (Berl). 1991;105(4):525-9. doi: 10.1007/BF02244374.
The role of genotype in the effects of selective D1 and D2 dopamine agonists and antagonists on behavioural despair (Porsolt's test) was studied. Mice of nine inbred strains showed significant interstrain differences in duration of immobility. The influence of dopaminergic drugs was assessed in six strains characterized by different levels of swimming activity. SKF 38393 (10 mg/kg), an agonist at D1 dopamine receptors, increased swimming activity, while the D1 antagonist SCH 23390 (0.2 and 0.5 mg/kg) reduced it, the effects being genotype dependent. The involvement of D2 dopamine receptors in the regulation of mouse behaviour in the forced swimming test was not so evident; the D2 agonist bromocriptine (10 mg/kg) produced no significant effect. The D2 agonist quinpirole (2.5 mg/kg) increased immobility in the majority of the mouse strains studied, while in CBA mice it resulted in a marked reduction of immobility. The D2 antagonist sulpiride (20 mg/kg) decreased immobility and increased active swimming only in two strains. The present results suggest a different role for D1 and D2 dopamine receptors in the regulation of swimming in the mouse.
研究了基因型在选择性D1和D2多巴胺激动剂及拮抗剂对行为绝望（波索尔特试验）影响中的作用。九个近交系小鼠在不动时间上表现出显著的品系间差异。在六个具有不同游泳活动水平特征的品系中评估了多巴胺能药物的影响。D1多巴胺受体激动剂SKF 38393（10毫克/千克）增加了游泳活动，而D1拮抗剂SCH 23390（0.2和0.5毫克/千克）则降低了游泳活动，其作用具有基因型依赖性。在强迫游泳试验中，D2多巴胺受体参与调节小鼠行为的情况不那么明显；D2激动剂溴隐亭（10毫克/千克）未产生显著影响。D2激动剂喹吡罗（2.5毫克/千克）在大多数所研究的小鼠品系中增加了不动时间，而在CBA小鼠中则导致不动时间显著减少。D2拮抗剂舒必利（20毫克/千克）仅在两个品系中减少了不动时间并增加了主动游泳。目前的结果表明D1和D2多巴胺受体在调节小鼠游泳中具有不同作用。
