大鼠体内2-氨基-4-硝基苯酚的经皮吸收

Percutaneous absorption of 2-amino-4-nitrophenol in the rat.

作者信息

Hofer H, Schwach G W, Fenzl C

出版信息

Food Chem Toxicol. 1982 Dec;20(6):921-3. doi: 10.1016/s0015-6264(82)80229-0.

Abstract

The absorption of 14C-labelled 2-amino-4-nitrophenol (ANP) in two hair dyeing formulations was investigated after application to the skin of rats. After 1 and 5 days, 0.21 and 0.36%, respectively, of the administered radioactivity was absorbed from formulation 1 which contained carboxymethylcellulose as a thickening agent. Absorption was greater (1.12% after 1 day, 1.67% after 5 days) from formulation 2 which contained oleic acid and isopropanol. Complementary studies of absorption after administration of [14C]ANP by sc injection or oral gavage were also carried out. The radioactivity was rapidly excreted, predominantly in the urine, in both cases. Biliary excretion was also detected in an oral study.

摘要

将两种染发配方中的14C标记的2-氨基-4-硝基苯酚（ANP）涂抹于大鼠皮肤后，对其吸收情况进行了研究。1天和5天后，含有羧甲基纤维素作为增稠剂的配方1分别吸收了0.21%和0.36%的给药放射性。含有油酸和异丙醇的配方2的吸收量更大（1天后为1.12%，5天后为1.67%）。还进行了皮下注射或灌胃给予[14C]ANP后吸收的补充研究。在这两种情况下，放射性均迅速排出，主要通过尿液排出。在一项口服研究中也检测到了胆汁排泄。