Tsomi V, Kalopissis G
Toxicol Eur Res. 1982 May;4(3):119-27.
The cutaneous penetration of certain number of oxidation dyestuffs for hair [p-aminophenol, 2,4-diaminoanisole, 2,4-diaminophenoxyethanol, resorcinol, 3-acetylamino-2,6-dimethylphenol and the indamine: N-(4'-hydroxyphenyl)-3-amino-6-methylbenzoquinoneimine], either alone or when formulated with other dyestuffs, and under various experimental conditions, has been evaluated in the hairless rat using C14 labeled molecules. It has been found that: Dyestuffs having indamine structures, formed by oxidation of their precursors (bases, couplers), for all practical purposes do not cross the cutaneous barrier. No fixation of those dyestuffs investigated (resorcinol, 2,4-diaminoanisole, 2,4-diaminophenoxyethanol) which do pass through the cutaneous barrier is found in either liver or thyroid of the experimental animals, 4 days after their topical application. The amount of the hairdye 3-acetylamino-2,6-dimethylphenol which penetrates the cutaneous barrier is constant for quantities of hairdye solution greater than or equal to 20 mg/cm2 of skin. The type and composition of the excipient used in the formulation of hairdyes plays an important role in their penetration.
使用碳 - 14标记的分子，在无毛大鼠身上评估了一定数量的用于头发的氧化染料[对氨基酚、2,4 - 二氨基苯甲醚、2,4 - 二氨基苯氧基乙醇、间苯二酚、3 - 乙酰氨基 - 2,6 - 二甲基苯酚以及吲哚胺：N - (4'-羟基苯基)-3 - 氨基 - 6 - 甲基苯醌亚胺]单独使用或与其他染料一起使用时，在各种实验条件下的皮肤渗透性。结果发现：由其前体（碱、偶合剂）氧化形成的具有吲哚胺结构的染料，实际上不会穿过皮肤屏障。在实验动物局部应用这些能够穿过皮肤屏障的染料（间苯二酚、2,4 - 二氨基苯甲醚、2,4 - 二氨基苯氧基乙醇）4天后，在其肝脏或甲状腺中均未发现染料的固定。当染发剂溶液的量大于或等于20mg/cm²皮肤时，染发剂3 - 乙酰氨基 - 2,6 - 二甲基苯酚穿透皮肤屏障的量是恒定的。用于染发剂配方的辅料的类型和组成在其渗透过程中起着重要作用。
