Meerson F Z, Kapel'ko V I, Gorina M S, Shchegol'kov A N, Larionov N P
Fiziol Zh SSSR Im I M Sechenova. 1978 Aug;64(8):1138-44.
Prolonged hypokinesia caused cardiac deadaptation in rabbits which resulted in diminishing of the left ventricle speed of contraction and relaxation joined later by a decreased vascular resistance. As a result, the ejection velocity as well as the stroke volume and the cardiac output were normal. The decrease of the relaxation speed became more obvious at a high heart rate and resulted in shortening of the diastolic pause and diminishing of cardiac output. Hearts of the hypokinetic animals were characterized by normal maximal pressure developed by a unit of myocardial mass at aorta clamping, decrease adrenoreactivity, and increased cholinoreactivity. This complex of changes is contrary to changes observed in adaptation to exercise, but is similar to changes observed in the compensatory hypertrophy of the heart.
长期运动不足导致家兔心脏失适应，致使左心室收缩和舒张速度降低，随后血管阻力下降。结果，射血速度以及每搏输出量和心输出量均正常。在高心率时，舒张速度的降低更为明显，导致舒张期停顿缩短和心输出量减少。运动不足动物的心脏特征为：主动脉夹闭时单位心肌质量产生的最大压力正常、肾上腺素反应性降低以及胆碱反应性增加。这种变化复合体与运动适应中观察到的变化相反，但与心脏代偿性肥大中观察到的变化相似。
