Yoshimura H, Yoshida H, Ogawa N
Yakubutsu Seishin Kodo. 1982 Dec;2(2):81-5.
The present study was conducted to investigate the effect of neonatal gonadal hormone treatments on the rat's emotionality in adult life. Female Sprague-Dawley rats treated subcutaneously on the day of birth with 100 micrograms of 17 beta-estradiol (E) or 1000 micrograms of testosterone propionate [TP] or 1000 micrograms of dihydrotestosterone[DHT] were tested in the open-field apparatus on 5 consecutive days at 6 months of age. All TP-treated rats and 6 out of 11 E-treated rats exhibited the persistent estrus on the vaginal smears, while DHT-treated rats and control rats did not show such changes in estrus cycle. Highly significant difference in either ambulation and defecation scores was found between persistent estrus and normal estrus cycle rats in E-treated group: persistent estrus rats showed higher ambulation and lower defecation than normal estrus cycle rats. As compared with the control level TP-treated persistent estrus rats showed a lower defecation score. These findings indicate that persistent estrus rats induced by E or TP are in the state of low emotionality. A possible relationship between the emotionality and the induction of mammary carcinomas was discussed.
本研究旨在探讨新生期性腺激素处理对成年大鼠情绪的影响。出生当天皮下注射100微克17β-雌二醇（E）、1000微克丙酸睾酮[TP]或1000微克双氢睾酮[DHT]的雌性斯普拉格-道利大鼠，在6个月龄时连续5天在旷场装置中进行测试。所有接受TP处理的大鼠和11只接受E处理的大鼠中有6只阴道涂片显示持续发情，而接受DHT处理的大鼠和对照大鼠的发情周期未出现此类变化。在接受E处理的组中，持续发情大鼠与正常发情周期大鼠在行走和排便评分上均存在极显著差异：持续发情大鼠的行走次数高于正常发情周期大鼠，排便次数低于正常发情周期大鼠。与对照水平相比，接受TP处理的持续发情大鼠排便评分较低。这些发现表明，由E或TP诱导的持续发情大鼠处于低情绪状态。讨论了情绪与乳腺癌诱导之间的可能关系。
