伴刀豆球蛋白A在体外诱导人嗜碱性粒细胞释放组胺。
Concanavalin A induced histamine release from human basophils in vitro.
作者信息
Magro A M, Bennich H
出版信息
Immunology. 1977 Jul;33(1):51-8.
Abstract
The site of interaction for concanavalin A (Con-A)-induced histamine release from human basophils was studied in vitro. Blocking the epsilon one determinant (D leads to 1) of IgE with high concentrations of monomer (Fab) anti-Depsilon1 does not significantly inhibit the quantity of histamine released by suboptimum concentrations of Fc specific anti-IgE. This indicates that the monomer anti-Depsilon1 does not have the capacity to sterically hinder the bridging of all of the determinants in the Cepsilon3 and Cepsilon4 domains (Fc'-epsilon-region) of IgE. The monomer anti-Depsilon1 does effectively inhibit release induced by suboptimum concentrations of Con-A. The data indicate that for suboptimum concentrations, Con-A activation is IgE mediated and takes place in the proximity of Depsilon1 and not at the membrane receptor for IgE.
摘要
在体外研究了伴刀豆球蛋白A（Con-A）诱导人嗜碱性粒细胞释放组胺的相互作用位点。用高浓度的单体（Fab）抗Dε1阻断IgE的ε1决定簇（D→1），并不能显著抑制次最佳浓度的Fc特异性抗IgE释放的组胺量。这表明单体抗Dε1没有空间阻碍IgE的Cε3和Cε4结构域（Fc'-ε区）中所有决定簇桥联的能力。单体抗Dε1确实有效地抑制了次最佳浓度的Con-A诱导的释放。数据表明，对于次最佳浓度，Con-A激活是由IgE介导的，发生在Dε1附近，而不是在IgE的膜受体处。
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