Michel F B, Dussourd d'Hinterland L, Pinel A M, Guendon R, Guerrero A J, Moutou M, Bansard J P
Arzneimittelforschung. 1980;30(1a):198-206.
Using a vaccine preparation administered by aerosol for respiratory anti-infectious purposes and corresponding to the original formula of ribosomes and membrane fractions of microbial germs, the authors investigated during a period of nine months whether an objective, transient or lasting stimulation of the total and specific immunoglobulin (Ig) appeared. They provide a statistical analysis based on several serum Ig measurements and demonstrate the stimulant and lasting effect of the vaccine in the production of specific Ig for a sample of patients compared with controls. In those treated they observed apparently disordered variations of the serum levels of the total Ig, which in fact correspond to the initiation of a dynamic equilibrium in relation to the immunogenicity of the vaccine, the initial level of the total Ig and the production of the specific Ig. Finally, after a booster sequence carried out five month after "primary vaccination", they established the restarting of production of specific Ig accompanied this time by a different dynamic response of the total Ig.
作者使用一种通过气雾剂给药用于呼吸道抗感染目的、对应微生物病菌核糖体和膜成分原始配方的疫苗制剂，在九个月的时间里研究是否出现了对总免疫球蛋白（Ig）和特异性免疫球蛋白的客观、短暂或持久刺激。他们基于多次血清Ig测量进行了统计分析，并证明与对照组相比，该疫苗对一组患者产生特异性Ig具有刺激和持久作用。在接受治疗的患者中，他们观察到总Ig血清水平明显无序的变化，而实际上这些变化对应于与疫苗免疫原性、总Ig初始水平和特异性Ig产生相关的动态平衡的启动。最后，在“初次接种疫苗”五个月后进行加强接种序列后，他们确定特异性Ig的产生重新开始，同时总Ig出现了不同的动态反应。
