McIntosh T J, Simon S A, MacDonald R C
Biochim Biophys Acta. 1980 Apr 24;597(3):445-63. doi: 10.1016/0005-2736(80)90219-9.
The interaction of n-alkanes (C6--C16) with phosphatidylcholine has been studied by the combined use of differential scanning calorimetry, X-ray diffraction and monolayer techniques. It has been found that the thermal properties and ultrastructure of lipid-alkane vesicles are strongly dependent on the length of the n-alkanes. Long alkanes, such as tetradecane and hexadecane, increase the transition temperature of dimyristoyl phosphatidylcholine and dipalmitoyl phosphatidylcholine, while the X-ray data indicate that these long alkanes align parallel to the lipid acyl chains. In contrast, shorter alkanes, such as hexane and octane, decrease and broaden the thermal transition and electron density profiles show that these alkanes increase bilayer width by partitioning between the apposing monolayers of the bilayer. For lipids in the gel and liquid crystalline states, the short alkanes form an alkane region in the geometric center of the bilayer.
通过差示扫描量热法、X射线衍射和单分子层技术相结合的方法，研究了正构烷烃（C6 - C16）与磷脂酰胆碱的相互作用。已发现脂质 - 烷烃囊泡的热性质和超微结构强烈依赖于正构烷烃的长度。长链烷烃，如十四烷和十六烷，会提高二肉豆蔻酰磷脂酰胆碱和二棕榈酰磷脂酰胆碱的转变温度，而X射线数据表明这些长链烷烃与脂质酰基链平行排列。相反，短链烷烃，如己烷和辛烷，会降低并拓宽热转变，电子密度分布图显示这些烷烃通过在双层相对的单分子层之间分配来增加双层宽度。对于处于凝胶态和液晶态的脂质，短链烷烃在双层的几何中心形成一个烷烃区域。
