Bohnert E, Humbel W G
Arch Dermatol Res. 1980;267(2):175-8. doi: 10.1007/BF00569103.
In 20 psoriatic patients under PUVA maintenance treatment blood samples had been collected imediately before and after the UVA irradiation. The DNA-repair activity has been determined in the isolated lymphocytes by the incorporation of 3H-thymidine during the first 3 h (inhibition of the semiconservative replication by hydroxyurea). There is evidence for an increased repair activity in the lymphocytes after PUVA treatment whereas the lymphocytes exposed only to 8-MOP (before UVA irradiation) show lower values. The difference is statistically significant 45 and 90 min after irradiation, but not any more after 3 h.
在20例接受补骨脂素加长波紫外线（PUVA）维持治疗的银屑病患者中，于长波紫外线（UVA）照射前后即刻采集血样。通过在最初3小时内掺入3H-胸腺嘧啶核苷（用羟基脲抑制半保留复制）来测定分离淋巴细胞中的DNA修复活性。有证据表明，PUVA治疗后淋巴细胞的修复活性增加，而仅暴露于8-甲氧基补骨脂素（8-MOP，在UVA照射前）的淋巴细胞显示出较低的值。照射后45分钟和90分钟时，差异具有统计学意义，但3小时后不再有差异。
