Ohnuma N, Kiyoki M, Bannai K, Naruchi T, Hashimoto Y, Noguchi T, Norman A W
Steroids. 1980 Jul;36(1):27-39. doi: 10.1016/0039-128x(80)90065-3.
A heretofore unknown metabolite of vitamin D3 was isolated from the 1 alpha, 24, 25-trihydroxyvitamin D3 fraction of lipid extracts obtained from plasma of rats which were given intravenous or oral doses of 100 pmol/100 g of either 1 alpha-hydroxyvitamin D3 or 1 alpha, 23-dihydroxyvitamin D3. Doses of 25-250 pmoles of the new metabolite when given to a vitamin D deficient rat were completely inactive in terms of stimulating the classic vitamin D response of bone calcium mobilization. The nature of the metabolism of 1 alpha-hydroxyvitamin D3 or 1 alpha, 25-dihydroxyvitamin D3 to the metabolite is not clear at the present time, but it is probable that neither of these steroids undergo side-chain cleavage to yield the new metabolite.
从静脉注射或口服100 pmol/100 g的1α-羟基维生素D3或1α,23-二羟基维生素D3的大鼠血浆脂质提取物的1α,24,25-三羟基维生素D3部分中分离出一种迄今未知的维生素D3代谢物。当给维生素D缺乏的大鼠注射25 - 250 pmol的这种新代谢物时，在刺激骨钙动员的经典维生素D反应方面完全没有活性。目前尚不清楚1α-羟基维生素D3或1α,25-二羟基维生素D3代谢为该代谢物的具体过程，但这些类固醇似乎都不会发生侧链裂解以产生这种新代谢物。
