ts P1和P3基因负责使携带甲型流感病毒H1N1或H3N2表面抗原的ts-1A2重组体达到令人满意的减毒水平。 - Suppr

Suppr

超能文献

ts P1 and P3 genes are responsible for satisfactory level of attenuation of ts-1A2 recombinants bearing H1N1 or H3N2 surface antigens of influenza A virus.

作者信息

Massicot J G, Murphy B R, van Wyke K, Huang K Y, Chanock R M

出版信息

Virology. 1980 Oct 15;106(1):187-90. doi: 10.1016/0042-6822(80)90241-x.

DOI:10.1016/0042-6822(80)90241-x

PMID:6893373

Abstract

摘要

相似文献

ts P1 and P3 genes are responsible for satisfactory level of attenuation of ts-1A2 recombinants bearing H1N1 or H3N2 surface antigens of influenza A virus.ts P1和P3基因负责使携带甲型流感病毒H1N1或H3N2表面抗原的ts-1A2重组体达到令人满意的减毒水平。

Virology. 1980 Oct 15;106(1):187-90. doi: 10.1016/0042-6822(80)90241-x.

Temperature-sensitive mutants of influenza A virus. Transfer of the two ts-1A2 ts lesions present in the Udorn/72-ts-1A2 donor virus to the influenza A/Alaska/6/77 (H3N2) wild type virus.甲型流感病毒的温度敏感突变体。将存在于乌栋/72-ts-1A2供体病毒中的两个ts-1A2 ts损伤转移至甲型流感病毒/阿拉斯加/6/77（H3N2）野生型病毒。

Arch Virol. 1980;65(2):175-86. doi: 10.1007/BF01317329.

Temperature-sensitive mutants of influenza A virus: evaluation of the Alaska/77-ts-1A2 temperature-sensitive recombinant virus in seronegative adult volunteers.甲型流感病毒温度敏感突变体：血清阴性成年志愿者中阿拉斯加/77-ts-1A2温度敏感重组病毒的评估

Arch Virol. 1980;65(2):169-73. doi: 10.1007/BF01317328.

[Molecular genetic analysis of a cold-adapted donor attenuation strain for a pediatric liver influenza vaccine, of recombinants based on it and of isolates from vaccinated children].[用于儿科肝脏流感疫苗的冷适应供体减毒株、基于该减毒株的重组体以及接种疫苗儿童分离株的分子遗传分析]

Vopr Virusol. 1984 Jan-Feb;29(1):22-8.

Recombinant cold-adapted attenuated influenza A vaccines for use in children: molecular genetic analysis of the cold-adapted donor and recombinants.用于儿童的重组冷适应减毒甲型流感疫苗：冷适应供体及重组体的分子遗传学分析

Infect Immun. 1984 Jun;44(3):730-3. doi: 10.1128/iai.44.3.730-733.1984.

Temperature-sensitive mutants of influenza A virus: evaluation of the A/Victoria/75-ts-1A2 temperature-sensitive recombinant virus in seronegative adult volunteers.甲型流感病毒温度敏感突变体：血清阴性成年志愿者中A/维多利亚/75-ts-1A2温度敏感重组病毒的评估

Infect Immun. 1979 Feb;23(2):249-52. doi: 10.1128/iai.23.2.249-252.1979.

Temperature-sensitive mutants of influenza A virus: transfer of the two temperature-sensitive lesions in the Udorn/72-ts-1A2 virus to the A2Hong Kong/123/77 (H1N1) wild-type virus.甲型流感病毒的温度敏感突变体：将乌东/72-ts-1A2病毒中的两个温度敏感损伤转移至A2香港/123/77（H1N1）野生型病毒。

Infect Immun. 1980 Jun;28(3):792-8. doi: 10.1128/iai.28.3.792-798.1980.

Analysis of virion RNA segments and polypeptides of influenza A virus recombinants of defined virulence.对具有特定毒力的甲型流感病毒重组体的病毒粒子RNA片段和多肽的分析。

Nature. 1978 Jun 29;273(5665):778-9. doi: 10.1038/273778a0.

Probable association of plaque size with neuraminidase subtype among H3N2 influenza A viruses. Brief report.甲型H3N2流感病毒中斑块大小与神经氨酸酶亚型的可能关联。简报。

Arch Virol. 1979;62(3):277-80. doi: 10.1007/BF01317560.

Naturally occurring temperature-sensitive influenza A viruses of the H1N1 and H3N2 subtypes.自然产生的H1N1和H3N2亚型温度敏感型甲型流感病毒。

J Gen Virol. 1980 Jun;48(Pt 2):383-9. doi: 10.1099/0022-1317-48-2-383.

引用本文的文献

Why is temperature sensitivity important for the success of common respiratory viruses?为什么温度敏感性对常见呼吸道病毒的成功传播很重要？

Rev Med Virol. 2021 Jan;31(1):1-8. doi: 10.1002/rmv.2153. Epub 2020 Aug 10.

Genetically engineered live attenuated influenza A virus vaccine candidates.基因工程减毒活甲型流感病毒候选疫苗

J Virol. 1997 Apr;71(4):2772-8. doi: 10.1128/JVI.71.4.2772-2778.1997.

Sequential addition of temperature-sensitive missense mutations into the PB2 gene of influenza A transfectant viruses can effect an increase in temperature sensitivity and attenuation and permits the rational design of a genetically engineered live influenza A virus vaccine.将温度敏感型错义突变依次添加到甲型流感转染病毒的PB2基因中，可提高温度敏感性并实现减毒，从而有助于合理设计基因工程甲型流感活病毒疫苗。

J Virol. 1995 Oct;69(10):5969-77. doi: 10.1128/JVI.69.10.5969-5977.1995.

Characterization of the temperature sensitive phenotype of the A/Ann Arbor/6/60 cold-adapted virus and its recombinants.A/安阿伯/6/60冷适应病毒及其重组体温度敏感表型的特征分析。

Infect Immun. 1981 May;32(2):960-3. doi: 10.1128/iai.32.2.960-963.1981.

Production and level of genetic stability of an influenza A virus temperature-sensitive mutant containing two genes with ts mutations.一种含有两个带有温度敏感（ts）突变基因的甲型流感病毒温度敏感突变株的产生及其遗传稳定性水平

Infect Immun. 1982 Jul;37(1):235-42. doi: 10.1128/iai.37.1.235-242.1982.

Evaluation of a phenotypic revertant of the A/Alaska/77-ts-1A2 reassortant virus in hamsters and in seronegative adult volunteers: further evidence that the temperature-sensitive phenotype is responsible for attenuation of ts-1A2 reassortant viruses.对A/阿拉斯加/77-ts-1A2重配病毒在仓鼠和血清阴性成年志愿者中的表型回复突变体的评估：温度敏感表型导致ts-1A2重配病毒减毒的进一步证据。

Infect Immun. 1982 May;36(2):645-50. doi: 10.1128/iai.36.2.645-650.1982.

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