Gonzalez R, Kraml M
Clin Biochem. 1980 Aug;13(4):141-3. doi: 10.1016/s0009-9120(80)90988-1.
We report a sensitive and specific method for the determination of butriptyline concentrations in serum by gas-liquid chromatography with a nitrogen phosphorus detector. The detection limit is 2 ng/ml, based on 3 ml of serum or plasma. The method has been validated in human volunteers receiving a single oral dose of 75 mg butriptyline hydrochloride.
我们报告了一种采用带氮磷检测器的气液色谱法测定血清中布替林浓度的灵敏且特异的方法。基于3毫升血清或血浆,检测限为2纳克/毫升。该方法已在接受单次口服75毫克盐酸布替林的人类志愿者中得到验证。