Szyszko E, Wejman W
J Chromatogr. 1981 Dec 4;219(2):291-6. doi: 10.1016/s0021-9673(00)87939-x.
Noxyptyline, i.e. 5-(2-dimethylaminoethyloxyimine)-5H-dibenzo[a,b] cyclohepta-1,4-diene hydrochloride, is an antidepressant. A new, direct method for its determination in substance and in tablets by means of gas chromatography has been developed. The results were compared with those of the spectrophotometric method, and the systematic errors(coefficient of variation) were 2.19% and 2.49%, respectively. Appropriate conditions were developed for the extraction of noxyptyline from plasma and urine, and the gas chromatographic method was applied for its determination. Within the concentration range 0.5-10 microgram/cm3, the systematic error after extraction from plasma was 4.61%, and after extraction from urine it was 2.08%. The recovery from plasma was 71.12 +/- 8%, and from urine it was 90.94 +/- 1.5%.
去甲替林，即5-(2-二甲基氨基乙氧基亚胺)-5H-二苯并[a,b]环庚-1,4-二烯盐酸盐，是一种抗抑郁药。已开发出一种通过气相色谱法直接测定其原料药及片剂的新方法。将结果与分光光度法的结果进行了比较，系统误差（变异系数）分别为2.19%和2.49%。确定了从血浆和尿液中提取去甲替林的适宜条件，并采用气相色谱法进行测定。在0.5 - 10微克/立方厘米的浓度范围内，从血浆中提取后的系统误差为4.61%，从尿液中提取后的系统误差为2.08%。血浆回收率为71.12±8%，尿液回收率为90.94±1.5%。
