Merz E A, Brinster R L, Brunner S, Chen H Y
J Reprod Fertil. 1981 Mar;61(2):415-8. doi: 10.1530/jrf.0.0610415.
The half-lives of labelled proteins were determined for mouse preimplantation embryo stages from the germinal vesicle oocyte to the early blastocyst. While no significant differences were found among half-lives for 1-cell stages, or among half-lives for cleavage stages, a significant (P less than 0.05) 28% decrease in half-life was observed between the 1-cell and the cleavage stages. Labelled protein half-lives were 18.2 and 13.1 h for the 1-cell and cleavage stages respectively. Fertilization probably initiates this increase in protein degradation rate although no significant decrease was detected until after the first cleavage.
测定了从生发泡卵母细胞到早期囊胚阶段的小鼠植入前胚胎中标记蛋白质的半衰期。虽然在1细胞阶段的半衰期之间或卵裂阶段的半衰期之间未发现显著差异，但在1细胞阶段和卵裂阶段之间观察到半衰期显著（P小于0.05）下降28%。1细胞阶段和卵裂阶段的标记蛋白质半衰期分别为18.2小时和13.1小时。受精可能启动了蛋白质降解率的这种增加，尽管直到第一次卵裂后才检测到显著下降。
