在大鼠肝脏灌注系统中1,25 - 二羟基维生素D3极性代谢物的生成。

Production of a polar metabolite of 1,25-dihydroxyvitamin D3 in a rat liver perfusion system.

作者信息

Kumar R, Nagubandi S, Londowski J M

出版信息

Dig Dis Sci. 1981 Mar;26(3):242-6. doi: 10.1007/BF01391637.

Abstract

When radiolabeled 1,25-dihydroxyvitamin D3 is added to the perfusion medium of a rat liver perfusion system, a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver and excreted in the bile. Addition of radiolabeled 1,25-dihydroxyvitamin D3 to the perfusion medium without a liver in the circuit results in no formation of the polar metabolite. These data suggest that a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver prior to being excreted in bile. Moreover, it is likely that polar metabolites of 1,25-dihydroxyvitamin D3 present in the bile of rats in vivo are formed in the liver.

摘要

当将放射性标记的1,25 - 二羟基维生素D3添加到大鼠肝脏灌注系统的灌注介质中时，1,25 - 二羟基维生素D3的一种极性代谢产物在肝脏中形成并随胆汁排出。在循环中没有肝脏的情况下，将放射性标记的1,25 - 二羟基维生素D3添加到灌注介质中不会形成极性代谢产物。这些数据表明，1,25 - 二羟基维生素D3的极性代谢产物在随胆汁排出之前在肝脏中形成。此外，体内大鼠胆汁中存在的1,25 - 二羟基维生素D3的极性代谢产物很可能是在肝脏中形成的。