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新生大鼠光疗诱导的低钙血症:褪黑素的预防作用

Phototherapy-induced hypocalcemia in newborn rats: prevention by melatonin.

作者信息

Hakanson D O, Bergstrom W H

出版信息

Science. 1981 Nov 13;214(4522):807-9. doi: 10.1126/science.6895262.

DOI:10.1126/science.6895262
PMID:6895262
Abstract

When young rats are exposed to white fluorescent light the concentration of calcium in their serum decreases. This effect is prevented by shielding the occiput, by inhibiting corticosterone synthesis, and by exogenous melatonin. Furthermore, the expected hypocalcemic response to cortisol injection is prevented by melatonin. Light-induced hypocalcemia may result from increased calcium uptake by bone when the blocking effect of melatonin decreases after pineal inhibition by transcranial illumination.

摘要

当幼鼠暴露于白色荧光灯下时,它们血清中的钙浓度会降低。通过遮蔽枕部、抑制皮质酮合成以及外源性褪黑素可防止这种效应。此外,褪黑素可防止对注射皮质醇预期的低钙血症反应。当经颅光照抑制松果体后褪黑素的阻断作用降低时,光诱导的低钙血症可能是由于骨骼对钙的摄取增加所致。

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Phototherapy-induced hypocalcemia in newborn rats: prevention by melatonin.新生大鼠光疗诱导的低钙血症:褪黑素的预防作用
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Melatonin Attenuates Intervertebral Disk Degeneration Maintaining Cartilaginous Endplate Integrity in Rats.
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