Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Department of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India.
Indian J Pediatr. 2021 Aug;88(8):805-808. doi: 10.1007/s12098-020-03655-8. Epub 2021 Feb 11.
Phototherapy-induced hypocalcemia has been postulated to result from a decline in serum melatonin levels. The present observational study evaluated the effects of phototherapy on serum calcium and melatonin levels, and assessed their correlation, if any. Eighty-nine neonates with a total serum bilirubin levels of 14.1 ± 2.8 mg/dL were recruited at the mean age of 51.9 ± 21.7 h. After a median interquartile range (IQR) duration of phototherapy for 24.0 (24-25.5) h, serum calcium levels decreased significantly, from 9.6 ± 0.8 to 9.4 ± 0.6 mg/dL; p = 0.02, leading to asymptomatic hypocalcemia in 2.2% of the neonates. Median (IQR) serum melatonin levels also decreased from 187.8 (133.5-227.6) to 176.3 (145.6-202.5) pg/mL after phototherapy, the difference being statistically insignificant. No significant correlation was documented between the duration of phototherapy with calcium and melatonin levels. The authors conclude that phototherapy resulted in a small but significant reduction of serum calcium levels without any significant correlation with serum melatonin.
光疗诱导的低钙血症被认为是血清褪黑素水平下降的结果。本观察性研究评估了光疗对血清钙和褪黑素水平的影响，并评估了它们之间的相关性（如果有的话）。89 名总胆红素水平为 14.1±2.8 mg/dL 的新生儿在平均年龄为 51.9±21.7 h 时被招募。在中位数（IQR）为 24.0（24-25.5）h 的光疗后，血清钙水平显著下降，从 9.6±0.8 降至 9.4±0.6 mg/dL；p=0.02，导致 2.2%的新生儿出现无症状性低钙血症。血清褪黑素水平的中位数（IQR）也从 187.8（133.5-227.6）降至 176.3（145.6-202.5）pg/mL，但差异无统计学意义。光疗时间与钙和褪黑素水平之间没有明显的相关性。作者得出结论，光疗导致血清钙水平略有但显著降低，与血清褪黑素水平无明显相关性。
