Nikolenko S A, Nazarenko V A
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1981;4(2):93-100.
The effect of different single doses of beta-blockers cordanum (talinolol) and obsidan was comparatively studied in 10 patients with angina pectoris of effort. The pharmacodynamic study was performed according to an original technique consisting in a sequence of monitored repeated identical treadmill exercise. The effect of the drug was evaluated by the reduction in ST-segment depression during exercise. Hemodynamic effect of cordanum was 1.7 lower than that of obsidan. The reduction of ST-segment depression effected by cordanum was 2.6 lower than in case of the corresponding doses of obsidan. The effect did not correlate with the heart rate and the double product; it terminated within 4--5 hrs.
对10例劳力性心绞痛患者比较研究了不同单剂量的β受体阻滞剂氯达洛尔（他林洛尔）和奥昔丹的效果。药效学研究采用一种原始技术进行，该技术包括一系列监测下的重复相同的跑步机运动。通过运动期间ST段压低的降低来评估药物的效果。氯达洛尔的血流动力学效应比奥昔丹低1.7。氯达洛尔引起的ST段压低的降低比相应剂量的奥昔丹低2.6。该效应与心率和双乘积无关；4 - 5小时内效应终止。
