Povarov L S, Gol'dberg L E, Bazhanov V S, Olsuf'eva E N, Averbukh L A
Antibiotiki. 1981 Nov;26(11):813-6.
13-Tert-butoxycarbonylhydrazone of rubomycin was prepared on interaction of rubomycin with tert-butoxycarbonylhydrazine. The new compound showed a high antitumor activity with respect to lymphosarcoma LIO-1 and Garding-Passey melanoma. The compound had no advantages over the initial rubomycin in the treatment of these tumors, was inferior to rubomycin with respect to its activity against leukemia P-388 and unlike rubomycin had practically no effect on leukemia L-1210.
柔红霉素的13-叔丁氧羰基腙是通过柔红霉素与叔丁氧羰基肼相互作用制备的。新化合物对淋巴肉瘤LIO-1和加丁-帕西黑色素瘤显示出高抗肿瘤活性。该化合物在治疗这些肿瘤方面相对于初始柔红霉素没有优势，在抗白血病P-388活性方面不如柔红霉素，并且与柔红霉素不同的是，它对白血病L-1210几乎没有作用。
