Ahmed S A, Penhale W J
Clin Exp Immunol. 1981 Sep;45(3):480-6.
Post-irradiation transplantation of normal thyroids under the renal capsule of syngenetic thymectomized and irradiated (Tx-X) rats leads to the development of thyroiditis in the ectopic grafted thyroids. A close correlation was observed between the extent of the lesions in the grafted and recipient's own thyroid. The histopathology of both grafted and recipient thyroid was similar and was characterized by infiltration with mononuclear cells together with some plasma cells. Conversely, grafting of affected thyroids from Tx-X rats to normal animals resulted in the regression of the lesion in the graft and no evidence thyroiditis was observed in either the graft or the recipient's thyroid when these were examined 60 days post-grafting. Thyroids derived from normal animals grafted to syngenetic normal rats were found to remain healthy and intact over a 60-day period. In contrast to normal animals, Tx-X rats were unable to reject totally in transplanted allogeneic thyroids by 28 days post-grafting, suggesting that some impairment of cell-mediated immunity follows this treatment. These findings indicate that the pathological change occurring in the thyroid gland of Tx-X rats is not attributable to the local effect of irradiation of the thyroids and adds further support to the concept that the process is immunologically mediated by thyroid-specific circulating components in the absence of normal immune regulatory function.
在同基因胸腺切除并受照射（Tx-X）的大鼠肾被膜下移植正常甲状腺，会导致异位移植的甲状腺发生甲状腺炎。观察到移植甲状腺和受体自身甲状腺的病变程度之间存在密切相关性。移植甲状腺和受体甲状腺的组织病理学相似，其特征为单核细胞连同一些浆细胞浸润。相反，将Tx-X大鼠的病变甲状腺移植到正常动物体内，会导致移植甲状腺的病变消退，并且在移植后60天检查时，无论是移植甲状腺还是受体甲状腺，均未观察到甲状腺炎的迹象。将正常动物的甲状腺移植到同基因正常大鼠体内，发现这些甲状腺在60天内保持健康完整。与正常动物不同，Tx-X大鼠在移植后28天内无法完全排斥移植的同种异体甲状腺，这表明这种处理会导致细胞介导免疫的某种损伤。这些发现表明，Tx-X大鼠甲状腺发生的病理变化并非归因于甲状腺局部照射的影响，进一步支持了这样一种概念，即该过程是在缺乏正常免疫调节功能的情况下，由甲状腺特异性循环成分免疫介导的。
