甲状腺炎大鼠自身抗体产生的部位。
Sites of autoantibody production in rats with thyroiditis.
作者信息
Weetman A P, McGregor A M, Rennie D P, Hall R
出版信息
Immunology. 1982 Jun;46(2):465-72.
Abstract
We have developed a thyroglobulin-specific haemolytic plaque assay and investigated potential sites of autoantibody synthesis in good and poor responder strains of rats immunized with thyroglobulin and in rats subjected to thymectomy and sub-lethal irradiation which subsequently develop thyroiditis spontaneously. The bone marrow appears to be the most important site of thyroglobulin antibody synthesis in all groups, but spleen and cervical lymph nodes are also involved. No thyroglobulin plaque-forming cells could be found in the thyroid. These results imply widespread involvement of the humoral immune system in organ-specific autoimmune processes.
摘要
我们开发了一种甲状腺球蛋白特异性溶血空斑试验，并研究了用甲状腺球蛋白免疫的反应良好和反应不佳的大鼠品系以及随后自发发生甲状腺炎的经胸腺切除和亚致死剂量照射的大鼠中自身抗体合成的潜在部位。在所有组中，骨髓似乎是甲状腺球蛋白抗体合成的最重要部位，但脾脏和颈部淋巴结也参与其中。在甲状腺中未发现甲状腺球蛋白空斑形成细胞。这些结果表明体液免疫系统广泛参与器官特异性自身免疫过程。
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本文引用的文献
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Clin Exp Immunol. 1981 Oct;46(1):1-8.
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Proc Natl Acad Sci U S A. 1981 Apr;78(4):2528-31. doi: 10.1073/pnas.78.4.2528.
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