Denson D D, Bridenbaugh P O, Turner P A, Phero J C, Raj P P
Anesth Analg. 1982 Sep;61(9):746-50.
A sensitive and reliable animal model for the objective physiologic and pharmacokinetic evaluation of spinal anesthesia has been developed. Using this model, spinal anesthesia using lidocaine (30 mg) in 7.5% dextrose with and without epinephrine was compared. Epinephrine did not alter the degree or duration of time to achieve maximum motor block. However, epinephrine did significantly increase the time for complete motor recovery. A significantly higher dermatome level of sensory block was achieved in the epinephrine-containing solutions, as well as a significantly longer time for complete recovery. This reflects a latent effect of epinephrine, as the time for two-segment regression was independent of epinephrine. Pharmacokinetic analysis showed no effect of epinephrine on absorption and elimination constants. The maximum plasma concentration and time to reach maximum plasma concentration were equal with and without epinephrine.
已经开发出一种用于脊髓麻醉客观生理和药代动力学评估的灵敏且可靠的动物模型。使用该模型，比较了在含7.5%葡萄糖的利多卡因（30毫克）中添加和不添加肾上腺素时的脊髓麻醉情况。肾上腺素并未改变达到最大运动阻滞的程度或时间。然而，肾上腺素确实显著延长了运动完全恢复的时间。含肾上腺素的溶液实现了显著更高的皮节感觉阻滞水平，以及完全恢复所需的显著更长时间。这反映了肾上腺素的潜在作用，因为两段回归时间与肾上腺素无关。药代动力学分析表明，肾上腺素对吸收和消除常数没有影响。无论有无肾上腺素，最大血浆浓度和达到最大血浆浓度的时间均相等。
