Shenoy M A, Biaglow J E, Varnes M E, Daniel J W
Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):725-8. doi: 10.1016/0360-3016(82)90721-0.
There have been many investigations on the radiosensitizing and cytotoxic effects of chlorpromazine, both in vitro and in vivo. We have extended the studies to include the chemotherapeutic effect of chlorpromazine on lymphosarcoma and on a mammary adenocarcinoma arising spontaneously in breeding female CBA mice. Chlorpromazine was ineffective in the former tumor but enhanced the longevity of tumor-bearing mice in the latter case. The drug was also observed to potentiate the hyperthermic killing of L5178Y cells and inhibit cellular oxygen utilization by cultured mammalian cells. The possible mechanisms involved are discussed.
关于氯丙嗪的放射增敏和细胞毒性作用，已经进行了许多体内和体外研究。我们将研究扩展到氯丙嗪对淋巴肉瘤和自发发生于繁殖期雌性CBA小鼠的乳腺腺癌的化疗作用。氯丙嗪对前一种肿瘤无效，但在后一种情况下延长了荷瘤小鼠的寿命。还观察到该药物可增强热对L5178Y细胞的杀伤作用，并抑制培养的哺乳动物细胞的氧利用。文中讨论了可能涉及的机制。
