131I-玫瑰红和99mTc-IDA衍生物在罗托综合征中的肝脏排泄情况。
The hepatic excretion of 131I-rose bengal and 99mTc-IDA derivatives in Rotor's syndrome.
作者信息
Galli G, Focacci C, Maini C L, Salvatori M, Troncone L, Fedeli G L, Rapaccini G L
出版信息
Eur J Nucl Med. 1982;7(7):311-7. doi: 10.1007/BF00253427.
Bilirubin kinetics and hepatobiliary excretion of some exogenous anions (BSP, 131I-rose bengal, diethyl and parabutly-IDA labeled with 99mTc) were studied in three patients presenting with Rotor's syndrome. Two were brothers; a nonjaundiced fraternal twin of one of them was also evaluated. The hepatic clearance of the radiopharmaceuticals was impaired in the affected patients but the degree of impairment was different among the tested anions, i.e., maximal for 99mTc-diethyl-IDA and minimal for 131I-rose bengal. Parabutyl-IDA was cleared better than the diethyl derivative. The metabolic derangement seems to be at the level of transfer from plasma to liver and of the hepatic storage, rather than at the level of hepatocyte excretory pathways, as in the case of Dubin-Johnson syndrome.
对三名患有罗托综合征的患者进行了胆红素动力学以及某些外源性阴离子（磺溴酞钠、131I-玫瑰红、用99mTc标记的二乙基亚氨基二乙酸和对丁基二乙基亚氨基二乙酸）的肝胆排泄研究。其中两名是兄弟；还对其中一人的非黄疸异卵双胞胎进行了评估。放射性药物的肝脏清除率在患病患者中受损，但受损程度在测试的阴离子之间有所不同，即99mTc-二乙基亚氨基二乙酸最大，131I-玫瑰红最小。对丁基二乙基亚氨基二乙酸的清除优于二乙基亚氨基二乙酸衍生物。代谢紊乱似乎发生在从血浆到肝脏的转运以及肝脏储存水平，而不是像杜宾-约翰逊综合征那样发生在肝细胞排泄途径水平。
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