Tarolo G L, Picozzi R, Palagi B, Cammelli F
Eur J Nucl Med. 1981 Dec;6(12):539-43. doi: 10.1007/BF00252666.
A method for comparative measurement of hepatic clearance of different hepatobiliary agents is described and the clinical use of diethyl-IDA and parabutyl-IDA is discussed. The study was performed with both radiopharmaceuticals in 13 patients with hepatobiliary disease with serum bilirubin ranging from 0.3 to 16.4 mg/100 ml. Diethyl-IDA is preferable for a qualitative evaluation of hepatobiliary disease because of its higher hepatic clearance and faster biliary excretion rate. Parabutyl-IDA is superior for measuring the hepatocytic uptake function, due to the low urinary excretion and the absence of an apparent re-entry from liver to plasma, even in patients with obstructive jaundice. In contrast, an appreciable re-entry can be demonstrated for diethyl-IDA.
本文描述了一种比较不同肝胆显像剂肝脏清除率的方法，并讨论了二乙基亚氨基二乙酸（diethyl-IDA）和对丁基 IDA 的临床应用。该研究对 13 例血清胆红素水平在 0.3 至 16.4 mg/100 ml 之间的肝胆疾病患者使用了这两种放射性药物。由于二乙基亚氨基二乙酸具有较高的肝脏清除率和较快的胆汁排泄率，因此更适合用于肝胆疾病的定性评估。对丁基 IDA 则更适合用于测量肝细胞摄取功能，因为即使在梗阻性黄疸患者中，其尿排泄率低且无明显的从肝脏再进入血浆的情况。相比之下，二乙基亚氨基二乙酸则可显示出明显的再进入现象。
