Milutinović B, Dujmović F, Malesević J
Department of Physiology, Faculty of Medicine, University of Novi Sad, Yugoslavia.
Am J Physiol Imaging. 1991;6(1):50-6.
Competition of diethyl-IDA and BSP during their synchronous passage through the liver was examined on an animal model. Rats were divided in three groups, according to the amount of diethyl-IDA or BSP administered. No significant influence of diethyl-IDA on the liver uptake of BSP was noticed compared to the controls, while BSP demonstrated a significant inhibitory effect on diethyl-IDA plasma-activity decrease. On the biliary pole of hepatocyte, a reciprocal inhibitory influence of both compounds was present, with significantly diminished biliary excretion of both BSP and diethyl-IDA. As the input of BSP was not decreased, there evidently appeared a storage of BSP within the liver. A mathematical model of both plasma and bile changes of the concentration (or activity) of these compounds was also proposed. For the vascular compartment the model is correct, while biliary excretion of diethyl-IDA is significantly changed in presence of BSP and the satisfactory fit cannot be easily obtained.
在动物模型上研究了二乙基亚氨基二乙酸（diethyl - IDA）和溴磺酚（BSP）在同步通过肝脏过程中的竞争情况。根据给予二乙基亚氨基二乙酸或溴磺酚的量，将大鼠分为三组。与对照组相比，未观察到二乙基亚氨基二乙酸对溴磺酚肝脏摄取有显著影响，而溴磺酚对二乙基亚氨基二乙酸血浆活性降低有显著抑制作用。在肝细胞的胆小管极，两种化合物存在相互抑制作用，溴磺酚和二乙基亚氨基二乙酸的胆汁排泄均显著减少。由于溴磺酚的输入未减少，肝脏内明显出现了溴磺酚的储存。还提出了这些化合物血浆和胆汁中浓度（或活性）变化的数学模型。对于血管腔室，该模型是正确的，而在存在溴磺酚的情况下，二乙基亚氨基二乙酸的胆汁排泄会显著改变，难以轻易获得满意的拟合结果。
