α-葡萄糖苷水解酶抑制剂脂联素的研究。III. α-葡萄糖苷水解酶的体外抑制活性和抗菌活性。

Studies on the alpha-glucoside hydrolase inhibitor, adiposin. III. alpha Glucoside hydrolase inhibitory activity and antibacterial activity in vitro.

作者信息

Kangouri K, Namiki S, Nagate T, Hara H, Sugita K, Omura S

出版信息

J Antibiot (Tokyo). 1982 Sep;35(9):1160-6. doi: 10.7164/antibiotics.35.1160.

DOI:10.7164/antibiotics.35.1160

Abstract

Adiposin-1 and -2 exhibited potent inhibitory activities against alpha-amylase, human salivary alpha-amylase and disaccharidases isolated from porcine small intestine. The effect of adiposin-1 and -2 on hydrolysis of glucoamylase was non-competitive. Adiposin showed antimicrobial activities against some Gram-positive bacteria, Gram-negative bacteria belonging to Enterobacteriaceae, Some anaerobic bacteria and some phytopathogenic fungi, and showed a synergistic effect on the antibacterial activity with some maltooligosaccharides. However, these antibacterial activities were suppressed by addition of various other saccharides.

摘要

脂肪素-1和-2对α-淀粉酶、人唾液α-淀粉酶以及从猪小肠分离出的双糖酶表现出强大的抑制活性。脂肪素-1和-2对葡糖淀粉酶水解的作用是非竞争性的。脂肪素对一些革兰氏阳性菌、属于肠杆菌科的革兰氏阴性菌、一些厌氧菌和一些植物病原真菌具有抗菌活性，并且与一些麦芽寡糖对抗菌活性具有协同作用。然而，添加各种其他糖类会抑制这些抗菌活性。