Mori T
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Nov;34(11):1819-26.
To investigate effects of epidural morphine and pentazocine on postoperative pain, eighty-eight women who have undergone gynecological abdominal surgery were studied. 1) As for onset of analgesia, there was statistically no significant difference between morphine and pentazocine. 2) The duration of analgesic effect of epidural morphine significantly lasted longer than epidural pentazocine. The duration of analgesic effect of epidural morphine showed a tendency to be longer in the groups of morphine 4 or 6mg than 2mg, but there was no significant difference between the groups of morphine 4 and 6mg. 3) On the postoperative first discharge of bowel gas, there was statistically no significant difference between morphine and pentazocine. The onset time of the gas discharge showed a tendency to be longer in the groups of morphine 4 or 6mg than 2mg. In case of pentazocine, it may be longer in 15mg than 10mg. 4) As for side effects, nausea, vomiting, thirsty, redness of the face and sweating were mainly observed. However, respiratory depression as well as sensory and motor disturbance which frequently observed after epidural injections of the local anesthetic were not recognized in these procedures. But circulatory depression and urinary retention were observed in only one cases of epidural morphine.
为研究硬膜外吗啡和喷他佐辛对术后疼痛的影响，对88例行妇科腹部手术的女性进行了研究。1）在镇痛起效方面，吗啡和喷他佐辛之间在统计学上无显著差异。2）硬膜外吗啡的镇痛作用持续时间明显长于硬膜外喷他佐辛。硬膜外吗啡4mg或6mg组的镇痛作用持续时间有长于2mg组的趋势，但吗啡4mg和6mg组之间无显著差异。3）在术后首次排气方面，吗啡和喷他佐辛之间在统计学上无显著差异。排气开始时间在吗啡4mg或6mg组有长于2mg组的趋势。对于喷他佐辛，15mg组可能长于10mg组。4）在副作用方面，主要观察到恶心、呕吐、口渴、面部潮红和出汗。然而，在这些操作中未发现硬膜外注射局部麻醉药后常见的呼吸抑制以及感觉和运动障碍。但仅在1例硬膜外吗啡病例中观察到循环抑制和尿潴留。
