Bárány E, Berrie C P, Birdsall N J, Burgen A S, Hulme E C
Br J Pharmacol. 1982 Dec;77(4):731-9. doi: 10.1111/j.1476-5381.1982.tb09353.x.
1 The binding properties of the muscarinic receptors in the ciliary muscle of cynomolgus monkeys have been evaluated. 2 The concentration of receptor binding sites is the highest yet reported. As found in many species and tissues, there are subclasses of agonist binding sites. Agonist binding is not affected by the non-hydrolysable guanosine triphosphate (GTP) analogue, GppNHp, suggesting that these receptors are not linked to adenylate cyclase. 3 Ciliary muscles made subsensitive by treatment with muscarinic agonists have a decreased receptor concentration but no other changes in the binding properties of the receptors could be detected.
1 已经评估了食蟹猴睫状肌中毒蕈碱受体的结合特性。2 受体结合位点的浓度是迄今报道的最高值。正如在许多物种和组织中所发现的那样，存在激动剂结合位点的亚类。激动剂结合不受不可水解的鸟苷三磷酸（GTP）类似物GppNHp的影响，这表明这些受体不与腺苷酸环化酶相连。3 用毒蕈碱激动剂处理后变得不敏感的睫状肌，其受体浓度降低，但未检测到受体结合特性的其他变化。
