Molnár J, Mucsi I, Mándi Y, Béládi I, Földeák S, Boda K
Int J Cancer. 1982 Dec 15;30(6):767-71. doi: 10.1002/ijc.2910300615.
A newly synthetized rutin derivative, rutin-N-mustard, showed a marked antiproliferative effect on NK/Ly ascites tumour cells in vivo. When administered i.p. or i.v., this compound increased the survival time of the animals, but oral administration had no such effect. The drug was not able to kill the tumour cells, since the chromium release from the rutin-N-mustard-treated tumour cells was the same as in the case of the controls. Tumour growth was completely inhibited in the animals when the cells were pretreated with 100 mg/kg rutin-N-mustard before transplantation. The results also showed that rutin-N-mustard has little effect on the xenogenization of NK/Ly tumour cells. We presume that the antiproliferative action of rutin-N-mustard is due to its alkylating activity.
一种新合成的芦丁衍生物——芦丁氮芥，在体内对NK/Ly腹水肿瘤细胞显示出显著的抗增殖作用。当腹腔注射或静脉注射时，该化合物可延长动物的存活时间，但口服给药则无此效果。该药物无法杀死肿瘤细胞，因为经芦丁氮芥处理的肿瘤细胞释放的铬与对照组相同。在移植前用100mg/kg芦丁氮芥预处理细胞后，动物体内的肿瘤生长被完全抑制。结果还表明，芦丁氮芥对NK/Ly肿瘤细胞的异种移植影响很小。我们推测芦丁氮芥的抗增殖作用归因于其烷基化活性。
