Arakawa M, Seino J, Kinoshita Y, Fukuda K, Saito T, Furuyama T
Tohoku J Exp Med. 1982 Dec;138(4):401-9. doi: 10.1620/tjem.138.401.
NeFA and NeFc were studied in various cases (115 cases). 5 cases were followed up for a long time. NeFA assay was done by the "microtest plate method". We detected the NeF activity for the first time in the cases of Sjögren syndrome (SjS) and SjS+SLE+Hashimoto's disease (Hashimoto). In some cases NeF activity disappeared after therapy, and in one case NeFA and NeFc were positive at first, but then only NeFA activity became negative following the adequate therapy. As to the antibody nature of NeF, the possibility was suggested that NeFA might be anti C3b autoantibody and NeFc might be anti C4b and/or C4b2a auto-antibody.
在各种病例（115例）中对新发现因子A（NeFA）和新发现因子C（NeFc）进行了研究。5例进行了长期随访。采用“微量滴定板法”进行NeFA检测。我们首次在干燥综合征（SjS）以及SjS+系统性红斑狼疮（SLE）+桥本氏病（Hashimoto）病例中检测到新发现因子活性。在某些病例中，新发现因子活性在治疗后消失，并且在1例中，NeFA和NeFc最初呈阳性，但在充分治疗后仅NeFA活性变为阴性。关于新发现因子的抗体性质，有人提出NeFA可能是抗C3b自身抗体，而NeFc可能是抗C4b和/或C4b2a自身抗体。
