Takenaka T, Konda C, Sakano T, Shimoyama M, Kitahara T, Minato K, Kitaoka H
Gan To Kagaku Ryoho. 1982 Feb;9(2):323-9.
A new combination chemotherapy(VEPA) was applied to 9 patients with advanced and/or non-resectable primary gastric lymphoma. Among 6 patients with measurable disease, there were 3 (50%) complete responses and 1 (17%) incomplete response. None of 3 patients with lymph node and/or anastomosis involvements at the gastrectomy have relapsed after 13 months to 32 months. Complications during chemotherapy with VEPA were mild myelosuppression and gastrointestinal disturbances, and severe alopecia. Only one paralytic ileus with vincristine occurred, but no cardiotoxicities with adriamycin were observed. This study indicates that VEPA therapy is effective in the patients with primary gastric lymphoma.
一种新的联合化疗方案（VEPA）应用于9例晚期和/或不可切除的原发性胃淋巴瘤患者。在6例可测量病灶的患者中，有3例（50%）完全缓解，1例（17%）部分缓解。3例胃切除时伴有淋巴结和/或吻合口受累的患者在13个月至32个月后均未复发。VEPA化疗期间的并发症为轻度骨髓抑制、胃肠道紊乱和严重脱发。仅发生1例与长春新碱相关的麻痹性肠梗阻，但未观察到与阿霉素相关的心脏毒性。本研究表明，VEPA治疗对原发性胃淋巴瘤患者有效。
