Seiler N, Graham A, Bartholeyns J
Cancer Res. 1981 Apr;41(4):1572-3.
We have studied the urinary excretion of free and acetylated polyamines in hepatoma-bearing Buffalo rats during the period of linear growth of the tumor mass. The excretion of nonconjugated polyamines was unchanged. N1-Acetylspermidine excretion did not parallel the linear increase in tumor mass but increased exponentially. Enhancement of N8-acetylspermidine excretion above control levels was observed only at a time when the average tumor mass was 35 +/- 9 (S.D.) g. shortly before the period when necrosis is usually observed. These data taken together with the analysis of urinary acetylpolyamines in rats bearing mammary tumors and in two melanoma patients show that the determination of the N1-acetylspermidine/N8-acetylspermidine ratio in urine may be of only limited value as an indicator for the presence of tumors.
我们研究了荷肝癌水牛大鼠在肿瘤块呈线性生长期间游离和乙酰化多胺的尿排泄情况。非共轭多胺的排泄没有变化。N1-乙酰亚精胺的排泄与肿瘤块的线性增加不平行，而是呈指数增加。仅在平均肿瘤块为35±9（标准差）g时，即在通常观察到坏死的时期前不久，才观察到N8-乙酰亚精胺排泄高于对照水平。这些数据与对荷乳腺肿瘤大鼠和两名黑色素瘤患者尿中乙酰化多胺的分析一起表明，测定尿中N1-乙酰亚精胺/N8-乙酰亚精胺比值作为肿瘤存在的指标可能价值有限。
