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1
B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells.B细胞耐受性。III. 木瓜蛋白酶介导的细胞表面IgD裂解对小鼠B细胞耐受性敏感性的影响。
J Exp Med. 1977 Jul 1;146(1):107-17. doi: 10.1084/jem.146.1.107.
2
B-cell tolerance. IV. Differential role of surface IgM and IgD in determining tolerance susceptibility of murine B cells.B细胞耐受性。IV. 表面IgM和IgD在决定小鼠B细胞耐受性易感性中的不同作用。
J Exp Med. 1977 Dec 1;146(6):1804-8. doi: 10.1084/jem.146.6.1804.
3
Cell surface immunoglobulin. XIX. Susceptibility of IgD and IgM on murine splenocytes to cleavage by papain.细胞表面免疫球蛋白。十九。小鼠脾细胞上IgD和IgM对木瓜蛋白酶裂解的敏感性。
J Immunol. 1976 Nov;117(5 Pt 1):1579-83.
4
In vitro tolerance induction of primed, IgD-negative murine spleen cells.致敏的、IgD 阴性小鼠脾细胞的体外耐受诱导
J Exp Med. 1981 Mar 1;153(3):653-64. doi: 10.1084/jem.153.3.653.
5
The role of receptor IgM and IgD in determining triggering and induction of tolerance in murine B cells.
Immunol Rev. 1979;43:69-95. doi: 10.1111/j.1600-065x.1979.tb00418.x.
6
B cell tolerance induction by cross-linking of membrane IgM, but not IgD, and synergy by cross-linking of both isotypes.通过膜IgM交联诱导B细胞耐受，而非IgD，且两种同种型交联具有协同作用。
J Immunol. 1993 Mar 1;150(5):1663-9.
7
Acquisition of surface IgD fails to protect from tolerance-induction. Both surface IgM- and surface IgD-mediated signals induce apoptosis of immature murine B lymphocytes.获得表面IgD不能防止耐受性诱导。表面IgM和表面IgD介导的信号均可诱导未成熟小鼠B淋巴细胞凋亡。
J Immunol. 1996 Feb 15;156(4):1328-32.
8
Role of surface IgM and IgD in the functional differentiation of human B lymphocytes: effect of papain treatment.
J Immunol. 1979 Aug;123(2):557-60.
9
B-cell tolerance. II. Trinitrophenyl human gamma globulin-induced tolerance in adult and neonatal murine B cells responsive to thymus-dependent and independent forms of the same hapten.B细胞耐受性。II. 三硝基苯基人γ球蛋白在成年和新生小鼠B细胞中诱导的耐受性，这些B细胞对半抗原的胸腺依赖性和非胸腺依赖性形式均有反应。
J Exp Med. 1977 Mar 1;145(3):778-83. doi: 10.1084/jem.145.3.778.
10
Role of IgD in the immune response and tolerance. II. Precursor analysis of murine B cells separated on the basis of surface IgD or treated with an anti-delta serum.IgD在免疫应答和免疫耐受中的作用。II. 基于表面IgD分离或用抗δ血清处理的小鼠B细胞的前体分析。
Eur J Immunol. 1978 Jan;8(1):13-6. doi: 10.1002/eji.1830080104.

引用本文的文献

1
Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging.分泌型IgM缺乏会改变视网膜格局，加剧与衰老相关的神经退行性变。
Immun Ageing. 2025 Feb 24;22(1):9. doi: 10.1186/s12979-025-00502-2.
2
Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas.从小鼠气管中分离和定量评估刷细胞
J Vis Exp. 2019 Jun 12(148). doi: 10.3791/59496.
3
Filamentous morphology of bacteria delays the timing of phagosome morphogenesis in macrophages.细菌的丝状形态会延迟巨噬细胞中吞噬体形态发生的时间。
J Cell Biol. 2013 Dec 23;203(6):1081-97. doi: 10.1083/jcb.201304095.
4
Role of stromal-cell derived factor-1 in the development of autoimmune diseases in non-obese diabetic mice.基质细胞衍生因子-1在非肥胖糖尿病小鼠自身免疫性疾病发展中的作用。
Immunology. 2002 Oct;107(2):222-32. doi: 10.1046/j.1365-2567.2002.01478.x.
5
Antigen receptor-initiated signals for B cell development and selection.用于B细胞发育和选择的抗原受体启动信号。
Immunol Res. 1998;17(1-2):155-62. doi: 10.1007/BF02786440.
6
Use of isolated immature-stage B cells to understand negative selection and tolerance induction at the molecular level.利用分离的未成熟阶段B细胞在分子水平上理解阴性选择和耐受性诱导。
Immunol Res. 1996;15(3):191-207. doi: 10.1007/BF02918249.
7
Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens.免疫球蛋白D缺陷小鼠能够对非胸腺依赖性和胸腺依赖性抗原产生正常的免疫反应。
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1887-91. doi: 10.1073/pnas.90.5.1887.
8
Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.免疫球蛋白D（IgD）缺陷小鼠揭示了IgD在抗原介导的B细胞募集中的辅助受体功能。
J Exp Med. 1993 Jan 1;177(1):45-55. doi: 10.1084/jem.177.1.45.
9
The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein.B淋巴细胞的IgM抗原受体与抑制素及一种抑制素相关蛋白相关联。
EMBO J. 1994 Aug 15;13(16):3782-92. doi: 10.1002/j.1460-2075.1994.tb06689.x.
10
Cross-linking of membrane immunoglobulin D, in the absence of T cell help, kills mature B cells in vivo.在没有T细胞辅助的情况下，膜免疫球蛋白D的交联会在体内杀死成熟B细胞。
J Exp Med. 1995 Feb 1;181(2):515-25. doi: 10.1084/jem.181.2.515.

本文引用的文献

1
Plaque Formation in Agar by Single Antibody-Producing Cells.琼脂中由单个抗体产生细胞形成的斑块。
Science. 1963 Apr 26;140(3565):405. doi: 10.1126/science.140.3565.405.
2
QUANTITATIVE TITRATIONS OF MOUSE H-2 ANTIBODIES USING CR-51-LABELLED TARGET CELLS.使用铬-51标记靶细胞对小鼠H-2抗体进行定量滴定
Transplantation. 1965 May;3:423-31. doi: 10.1097/00007890-196505000-00011.
3
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
4
Immunization of normal mouse spleen cell suspensions in vitro.体外对正常小鼠脾细胞悬液进行免疫接种。
Science. 1966 Aug 26;153(3739):1004-6. doi: 10.1126/science.153.3739.1004.
5
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
6
An in vitro primary immune response to 2,4,6-trinitrophenyl substituted erythrocytes: response against carrier and hapten.对2,4,6-三硝基苯基取代红细胞的体外初次免疫反应：针对载体和半抗原的反应。
J Immunol. 1970 Jun;104(6):1558-61.
7
Cell surface immunoglobulin. IX. A new method for the study of synthesis, intracellular transport, and exteriorization in murine splenocytes.细胞表面免疫球蛋白。IX。一种研究小鼠脾细胞中合成、细胞内运输和外化的新方法。
J Exp Med. 1974 Jun 1;139(6):1599-620. doi: 10.1084/jem.139.6.1599.
8
Differential stimulation of precursor cells and carrier-specific thymus-derived cell activity in the in vivo reponse to heterologous erythrocytes in mice.小鼠体内对异种红细胞反应中前体细胞的差异刺激及载体特异性胸腺来源细胞活性
J Immunol. 1972 Jan;108(1):54-8.
9
Ontogeny of B lymphocytes. II. Relative rates of appearance of lymphocytes bearing surface immunoglobulin and complement receptors.B淋巴细胞的个体发生。II. 带有表面免疫球蛋白和补体受体的淋巴细胞的相对出现率。
J Exp Med. 1974 May 1;139(5):1125-41. doi: 10.1084/jem.139.5.1125.
10
Cell surface immunoglobulin. X. Identification of an IgD-like molecule on the surface of murine splenocytes.细胞表面免疫球蛋白。X. 小鼠脾细胞表面一种类IgD分子的鉴定。
J Exp Med. 1974 Nov 1;140(5):1427-31. doi: 10.1084/jem.140.5.1427.

B细胞耐受性。III. 木瓜蛋白酶介导的细胞表面IgD裂解对小鼠B细胞耐受性敏感性的影响。

B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells.

作者信息

Cambier J C, Vitetta E S, Kettman J R, Wetzel G M, Uhr J W

出版信息

J Exp Med. 1977 Jul 1;146(1):107-17. doi: 10.1084/jem.146.1.107.

DOI:10.1084/jem.146.1.107
PMID:68987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180726/
Abstract

Under defined conditions, papain removes IgD from cells while leaving IgM, H-2, Ia, Lyb-2, and complement receptor intact. The effect of such treatment with papain on the induction of tolerance in murine splenic B cells was determined in an in vitro system. Treatment of the cells with papain has no effect on subsequent antibody responsiveness presumably because surface receptors regenerate before and during incubation with immunogen. Removal of increasing amounts of IgD results in increasing susceptibility of thymus-dependent responsive cells to tolerance induction. The tolerance susceptibility of thymus-independent responsive cells, which we have previously suggested are immature cells that bear only IgM, is unaffected by cleavage of IgD. If cells are incubated for 24 h after treatment with papain, cell surface IgD and tolerance resistance return. These results indicate that a surface molecule affects susceptibility of B cells to induction of tolerance and suggest that this molecule may be IgD.

摘要

在特定条件下，木瓜蛋白酶可从细胞中去除IgD，而IgM、H-2、Ia、Lyb-2和补体受体则保持完整。在体外系统中测定了用木瓜蛋白酶进行这种处理对小鼠脾B细胞耐受诱导的影响。用木瓜蛋白酶处理细胞对随后的抗体反应性没有影响，这可能是因为表面受体在与免疫原孵育之前和期间会再生。去除越来越多的IgD会导致胸腺依赖性反应细胞对耐受诱导的敏感性增加。我们之前认为胸腺非依赖性反应细胞是仅携带IgM的未成熟细胞，其对耐受的敏感性不受IgD裂解的影响。如果细胞在用木瓜蛋白酶处理后孵育24小时，细胞表面IgD和耐受抗性会恢复。这些结果表明，一种表面分子会影响B细胞对耐受诱导的敏感性，并表明该分子可能是IgD。