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用于测定血浆和组织中2,4-二氨基-5-(3,4-二氯苯基)-6-甲基嘧啶（美托普林）水平的定量高压液相色谱法及其在脑毛细血管通透系数测量中的应用

Quantitative high-pressure liquid chromatographic procedure for the determination of plasma and tissue levels of 2,4-diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine (metoprine) and its application to the measurement of brain capillary permeability coefficients.

作者信息

Levin E M, Meyer R B, Levin V A

出版信息

J Chromatogr. 1978 Aug 21;156(1):181-7. doi: 10.1016/s0021-9673(00)83138-6.

DOI:10.1016/s0021-9673(00)83138-6
PMID:689956
Abstract

A high-pressure liquid chromatographic assay for metoprine levels in aqueous media, serum, and tissue extracts has been developed that can measure concentrations of the drug in the 25-100 ng range with accuracy, reproducibility, and ease. The half-time for metoprine disappearance from rat plasma and capillary permeability coefficients for metroprine in rate brain tissue determined with this method are in excellent agreement with values determined for related drugs using labeled compounds.

摘要

已开发出一种用于测定水性介质、血清和组织提取物中甲氯普胺水平的高压液相色谱分析方法，该方法能够准确、可重复且轻松地测量25-100纳克范围内的药物浓度。用该方法测定的甲氯普胺从大鼠血浆中消失的半衰期以及甲氯普胺在大鼠脑组织中的毛细血管通透性系数，与使用标记化合物对相关药物测定的值高度一致。

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